CBD or cannabidiol is deprived of psychoactive properties, but it can help with various diseases
Recently, the main topics medical marijuana has been surfacing more and more regularly in foreign media, scientists are trying their best to have permissions and funding for research of this type, believing in its promise, and in many countries of the world, decriminalization and legalization are underway.
Most hype now causes a substance such as for instance CBD or cannabidiol within the hemp plant. Today it is found anywhere – from food to decorative cosmetics and quite legally purchased best cbd gummies uk in online stores in the proper execution of oil. And all because CBD does not have psychoactive properties, unlike tetrahydrocannabinol (THC), but it’s healing properties.
Since CBD is an active element of marijuana itself, you will get make money from it by smoking a joint in the old fashioned way. The main thing is always to ensure that a level with a predominance of this particular substance, as opposed to THC, is clogged in your joint in the event that you would like to relax and relieve anxiety or pain, and not, as usual, get stuck in the couch, unsuccessfully trying to control paranoia.
Let’s attempt to figure out how this magical cannabidiol works, based on the latest data from the world of science and the ability of consumers using CBD as a medicine, and not for fun.
The difference between the effects of CBD and THC
Since cannabidiol is not a psychoactive substance, you can’t get high from it, but it’s easy to increase your productivity, relieve anxiety and relieve pain. When working with CBD, thoughts are not confused, memory does not deteriorate, and consequently of muscle relaxation, you may not become a vegetable, as is the case with smoking cannabis varieties with a predominance of THC.
If the ratio of these substances is approximately exactly the same, then you definitely will see a slight euphoric and the above-mentioned beneficial effects at exactly the same time. At the same time frame, such negative consequences as paranoia, dry mouth, becoming dry and redness of the eyes, hunger and gluttony, drowsiness, and short-term memory problems, which are generally brought on by THC, do not occur. Such varieties are most often used as a painkiller.
Although CBD works well alone, some experts still insist that in combination with other active the different parts of marijuana, it brings more benefits:
“To attain a much better therapeutic effect, you need a mix of cannabidiol, THC, and terpenoid phytochemicals,” says psychiatrist doctor at Harvard Medical School Lester Greenspoon.
However, how exactly this effect is achieved, scientists can not even say with accuracy. This knowledge gap is caused, to begin with, by deficiencies in research data, since the field of studying the healing properties of hemp remains in its infancy. However the gradual legalization of medical marijuana shows that scientists will soon have significantly more freedom due to their experiments. So hold the fists, hope and believe.
What diseases cannabidiol helps to deal with
Some scientific papers claim that CBD has anti-inflammatory, analgesic and antipsychotic properties. In this regard, doctors hope that substance may help pharmaceutical companies to develop effective drugs against many disorders and diseases followed by similar symptoms.
The set of such diseases includes, but isn’t restricted to such pathological conditions:
To date, there are no full-fledged drugs centered on CBD to combat these disorders, but many patients declare that the substance helps them to alleviate and even completely get rid of the symptoms.
Recently in the USA, where marijuana remains on the list of the very most dangerous psychoactive substances, there is a real breakthrough in the field of pharmaceuticals – the Federal Food and Drug Administration (FDA) has approved the launch of the initial marijuana-based antiepileptic drug on the American market under Epidiolex name.
Its main component is precisely cannabidiol, the anticonvulsant effect of that the FDA has confirmed using its tests. Today, Epidiolex is employed to take care of severe forms of epilepsy and such rare disorders that cause frequent and intense cramps in children, like Drave syndrome and Lenno-Gastaut syndrome.
And yet, before Epidiolex, there were other drugs based on the the different parts of marijuana. As an example, the Belgian company Solvay Pharmaceuticals back 1985 created Marinol (dronabinol), a medication that’s simply a synthetic THC, that will be still used today to increase the appetite of cancer patients undergoing chemotherapy.
In 2010, British pharmaceutical group GW Pharmaceuticals developed Sativex, a drug containing equal parts of CBD and THC, to alleviate muscle cramps and other symptoms of multiple sclerosis.
The mechanism of action of cannabidiol
Although there is still not so much data on what CBD includes a beneficial impact on your body, scientists still have some ideas with this subject. Surprisingly, cannabidiol does not bind to the active sites of the cannabinoid receptors CB1 and CB2, as does exactly the same THC. However it interacts with the GPR55 protein secreted in the brain and peripheral organs. Researchers believe that determines its antispasmodic effect.
In the brain, CBD regulates the synaptic transmission process, during which signaling molecules are transmitted in one neuron to another. The connections between these brain cells grow stronger when GPR55 is activated.
Convulsions occur when neurons become too active in signaling, flashing more regularly than necessary. Cannabidiol blocks the GPR55 protein, thus preventing overload of the synaptic transmission system, according to Ben Wally, head of research at GW Pharmaceuticals.
The connection of this protein with CBD is confirmed by experiments with genetically modified rodents by which epileptic seizures were caused. Those animals by which GPR55 was present responded to cannabidiol treatment, and rats without protein continued to experience convulsions.
Wally also believes that CBD can subscribe to the desensitization of the TRPV1 protein, that will be active in the transport of ions and calcium within the body, which also helps relieve cramping. First, cannabidiol activates this protein, but then quickly decreases the sensitivity of the ion channel, effectively blocking the transport of calcium into cells. By analogy with GPR55, animals that lack TRPV1 do not react to CBD.
Finally, this substance interacts with the channel of transport of adenosine, an anticonvulsant substance made by the body. Wally believes that cannabidiol suppresses seizures, mainly because of its impact on adenosine, but more experiments are essential to ensure this hypothesis.
This kind of wide variety of areas by which CBD is active allows scientists to suggest that substance may be useful in the treating motor disorders, such as for instance Parkinson’s disease. And the interaction with serotonin receptors shows that cannabidiol can be used to take care of depression, anxiety and psychotic stages of bipolar disorder and schizophrenia.
Nevertheless, many researchers, such as for instance Roger Pertwee, a professor at the University of Aberdeen and the head of the pharmacology department of GW Pharmaceuticals, insist that without clinical data it cannot be confidently stated that the interaction of CBD with one of these receptors and proteins means that it causes a therapeutic effect of this substance.
High CBD Marijuana Varieties
Finally, we will give you a listing of popular cannabidiol-dominated varieties so do you know what to enquire about next time in your telegram supermarket: